Aims: HIV infection may be associated with an increased recurrence rate of myocardial infarction. Our aim was to\ndetermine whether HIV infection is a risk factor for worse outcomes in patients with coronaray artery disease.\nMethods: We compared data aggregated from two ongoing cohorts: (i) the Acute Myocardial Infarction in Switzerland\n(AMIS) registry, which includes patients with acute myocardial infarction (AMI), and (ii) the Swiss HIV Cohort Study (SHCS),\na prospective registry of HIV-positive (HIV+) patients. We included all patients who survived an incident AMI occurring on\nor after 1st January 2005. Our primary outcome measure was all-cause mortality at one year; secondary outcomes included\nAMI recurrence and cardiovascular-related hospitalisations. Comparisons used Cox and logistic regression analyses, respectively.\nResults: There were 133 HIV+, (SHCS) and 5,328 HIV-negative [HIV-] (AMIS) individuals with incident AMI. In the SHCS\nand AMIS registries, patients were predominantly male (72% and 85% male, respectively), with a median age of 51 years\n(interquartile range [IQR] 46ââ?¬â??57) and 64 years (IQR 55ââ?¬â??74), respectively. Nearly all (90%) of HIV+ individuals were on\nsuccessful antiretroviral therapy. During the first year of follow-up, 5 (3.6%) HIV+ and 135 (2.5%) HIV- individuals died. At\none year, HIV+ status after adjustment for age, sex, calendar year of AMI, smoking status, hypertension and\ndiabetes was associated with a higher risk of death (HR 4.42, 95% CI 1.73-11.27). There were no significant\ndifferences in recurrent AMIs (4 [3.0%] HIV+ and 146 [3.0%] HIV- individuals, OR 1.16, 95% CI 0.41-3.27) or in\nhospitalization rates (OR 0.68 [95% CI 0.42-1.11]).\nConclusions: HIV infection was associated with a significantly increased risk of all-cause mortality one year after\nincident AMI.
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